In this diagram of G-protein-coupled receptor activation, the alpha, beta, and gamma subunits are shown with distinct relationships to the plasma membrane. After exchange of GDP with GTP on the alpha ...

In the evolutionary history of life, the ability of a cell to separate its inner world from the external environment was an ...

To understand why a defect in a particular protein causes disease, we must know not only what that protein does but how. Studying its structure can reveal its mechanisms of action, but imaging ...