The N-end rule pathway is a conserved proteolytic system that governs protein turnover by recognising specific destabilising residues at the N-terminus of substrates – so‐called N‐degrons. This ...

This article is based on a poster originally authored by Mat Calder, Ben Durham, Amy Prosser, Miguel Coelho, Aimee Blair, Jack Cobb, Marta Falcicchio, Ruben Alvarez Fernandez, Emma Ford, Alberto ...

When targeting problem proteins involved in causing or spreading disease, a drug will often clog up a protein's active site so it can't function and wreak havoc. New strategies for dealing with these ...

Researchers have identified the drivers of an extracellular protein degradation pathway, which could be the key to a new generation of therapeutics. In a recent study, chemists at Stanford University ...

When targeting problem proteins involved in causing or spreading disease, a drug will often clog up a protein’s active site so it can’t function and wreak havoc. New strategies for dealing with these ...

Edited By: Karen Young Kreeger C.L. Ward, S. Omura, R.R. Kopito, "Degradation of CFTR by the ubiquitin-proteasome pathway," Cell, 83:121-7, 1995. (Cited in nearly 50 publications as of March 1997) ...

Targeted protein degradation (TPD) approaches including PROTAC and molecular glue have revolutionized drug discovery. However, in part due to complication of the ubiquitination and related ...

Intracellular protein trafficking and secretion of proteins into the extracellular environment are sequential and tightly regulated processes in eukaryotic cells. Conventionally, proteins that are ...

United States Targeted Protein Degradation Market is innovatory pharmacological perception that grants practical drug development chances and is expected to announce a new paradigm in modern ...

Edited by: Thomas W. Durso and Karen Young Kreeger M. Hochstrasser, "Ubiquitin, proteasomes, and the regulation of intracellular protein degradation," Current Opinion in Cell Biology, 7:215-23, 1995. ...